Rifamycin O, An Alternative Anti-Mycobacterium abscessus Agentopen access
- Authors
- Bui Thi Bich Hanh; Park, June-Woo; Kim, Tae Ho; Kim, Jae-Sung; Yang, Chul-Su; Jang, Kiseok; Cui, Jinsheng; Oh, Dong-Chan; Jang, Jichan
- Issue Date
- Apr-2020
- Publisher
- Multidisciplinary Digital Publishing Institute (MDPI)
- Keywords
- rifamycin; Mycobacterium abscessus; zebrafish bacterial infection; drug resistance; non-tuberculous mycobacteria
- Citation
- Molecules, v.25, no.7, pp 1 - 15
- Pages
- 15
- Indexed
- SCIE
SCOPUS
- Journal Title
- Molecules
- Volume
- 25
- Number
- 7
- Start Page
- 1
- End Page
- 15
- URI
- https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/1196
- DOI
- 10.3390/molecules25071597
- ISSN
- 1420-3049
1420-3049
- Abstract
- Mycobacterium abscessus is the most difficult-to-treat nontuberculous mycobacteria because of its resistance to many antibiotics. In this study, we screened the Korea Chemical Bank library for a bioluminescent reporter assay to identify molecules capable of acting against M. abscessus. On application of the assay, rifamycin O showed excellent in vitro activity with a narrow range of the minimum inhibitory concentration required to inhibit the growth of 90% of the bacterium (MIC90 = 4.0-6.2 mu M); its in vivo efficacy in the zebrafish (Danio rerio) infection model was comparable to that of rifabutin at 25 mu M. Furthermore, rifamycin O did not show significant toxicity in cells and the zebrafish model. These results are the first in vivo indication that rifamycin O may be a drug candidate for treating M. abscessus infections.
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