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Characterization of in vitro metabolites of methylenedioxypyrovalerone (MDPV): An N-oxide metabolite formation mediated by flavin monooxygenase
- Authors
- Kim, In Sook; Rehman, Shaheed Ur; Choi, Min Sun; Jang, Moonhee; Yang, Wonkyung; Kim, Eunmi; Yoo, Hye Hyun
- Issue Date
- Nov-2016
- Publisher
- Elsevier BV
- Keywords
- Methylenedioxypyrovalerone; Metabolite; N-oxide; FMO; Human liver microsomes
- Citation
- Journal of Pharmaceutical and Biomedical Analysis, v.131, pp.160 - 166
- Indexed
- SCIE
SCOPUS
- Journal Title
- Journal of Pharmaceutical and Biomedical Analysis
- Volume
- 131
- Start Page
- 160
- End Page
- 166
- ISSN
- 0731-7085
- Abstract
- Methylenedioxypyrovalerone (MDPV) has emerged in recent years as a-recreational substance with psychostimulant properties. In this study, in vitro metabolites of MDPV were characterized based on liquid chromatography/quadrupole-time-of-flight mass spectrometry(LC/QTOF MS). MDPV was incubated with human liver microsomes, human recombinant cDNA-expressed cytochrome P450 enzymes and flavin monooxygenase (FMO). MDPV was metabolized to yield eight metabolites (M1-M8)with major metabolic reactions such as demethylenation and oxidation. Among them, M6 was assigned as an N-oxide metabolite. FMO was found to be a principal enzyme responsible for the formation of M6; FMO1 and FMO3 were the main enzymes involved in N-oxidation of MDPV. (C) 2016 Elsevier B.V. All rights reserved.
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Related Researcher
- Yoo, Hye Hyun
- COLLEGE OF PHARMACY (DEPARTMENT OF PHARMACY)