Self-healing Elastin-bioglass Hydrogels
- Authors
- Zeng,Qiongyu; Desai,Malav S.; Jin, Hyo-Eon; Lee, Ju Hun; Chang, Jiang; Lee,Seung-Wuk
- Issue Date
- Aug-2016
- Publisher
- American Chemical Society
- Citation
- Biomacromolecules, v.17, no.8, pp.2619 - 2625
- Indexed
- SCIE
SCOPUS
- Journal Title
- Biomacromolecules
- Volume
- 17
- Number
- 8
- Start Page
- 2619
- End Page
- 2625
- URI
- https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/13110
- DOI
- 10.1021/acs.biomac.6b00621
- ISSN
- 1525-7797
- Abstract
- Tailorable hydrogels that are mechanically robust, injectable, and self-healable, are useful for many
biomedical applications including tissue repair and drug delivery. Here we use biological and chemical engineering
approaches to develop a novel in situ forming organic/inorganic composite hydrogel with dynamic aldimine crosslinks using elastin-like polypeptides (ELP) and bioglass (BG). The resulting ELP/BG biocomposites exhibit tunable gelling behavior and mechanical characteristics in a composition and concentration dependent manner. We also demonstrate self-healing in the ELP/BG hydrogels by successfully reattaching severed pieces as well as through rheology. In addition, we show the strength of genetic engineering to easily customize ELP by fusing cell-stimulating “RGD” peptide motifs. We showed that the
resulting composite materials are cytocompatible as they support the cellular growth and attachment. Our robust in situ forming
ELP/BG composite hydrogels will be useful as injectable scaffolds for delivering cell and drug molecules to promote soft tissue
regeneration in the future.
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