Aspirin induces IL-4 production: augmented IL-4 production in aspirin-exacerbated respiratory diseaseopen access
- Authors
- Kong, Su-Kang; Kim, Byung Soo; Uhm, Tae Gi; Chang, Hun Soo; Park, Jong Sook; Park, Sung Woo; Park, Choon-Sik; Chung, Il Yup
- Issue Date
- Jan-2016
- Publisher
- 생화학분자생물학회
- Citation
- Experimental and Molecular Medicine, v.48, pp.1 - 10
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- Experimental and Molecular Medicine
- Volume
- 48
- Start Page
- 1
- End Page
- 10
- URI
- https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/14649
- DOI
- 10.1038/emm.2015.96
- ISSN
- 1226-3613
- Abstract
- Aspirin hypersensitivity is a hallmark of aspirin-exacerbated respiratory disease (AERD), a clinical syndrome characterized by the severe inflammation of the respiratory tract after ingestion of cyclooxygenase-1 inhibitors. We investigated the capacity of aspirin to induce interleukin-4 (IL-4) production in inflammatory cells relevant to AERD pathogenesis and examined the associated biochemical and molecular pathways. We also compared IL-4 production in peripheral blood mononuclear cells (PBMCs) from patients with AERD vs aspirin-tolerant asthma (ATA) upon exposure to aspirin. Aspirin induced IL-4 expression and activated the IL-4 promoter in a report assay. The capacity of aspirin to induce IL-4 expression correlated with its activity to activate mitogen-activated protein kinases, to form DNA-protein complexes on P elements in the IL-4 promoter and to synthesize nuclear factor of activated T cells, critical transcription factors for IL-4 transcription. Of clinical importance, aspirin upregulated IL-4 production twice as much in PBMCs from patients with AERD compared with PBMCs from patients with ATA. Our results suggest that IL-4 is an inflammatory component mediating intolerance reactions to aspirin, and thus is crucial for AERD pathogenesis.
- Files in This Item
-
Go to Link
- Appears in
Collections - COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY > ERICA 의약생명과학과 > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.