Anticancer effect of docetaxel/hydroxypropyl-beta-cyclodextrin complex without histamine release
- Authors
- Kim, Tae Kon; Yoo, Hye Hyun
- Issue Date
- Dec-2015
- Publisher
- SPRINGER
- Keywords
- Docetaxel; HP-beta-CD; Anticancer activity; Hypersensitivity
- Citation
- Journal of Inclusion Phenomena and Macrocyclic Chemistry , v.83, no.3-4, pp.355 - 361
- Indexed
- SCOPUS
- Journal Title
- Journal of Inclusion Phenomena and Macrocyclic Chemistry
- Volume
- 83
- Number
- 3-4
- Start Page
- 355
- End Page
- 361
- URI
- https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/16474
- DOI
- 10.1007/s10847-015-0571-2
- ISSN
- 1388-3127
- Abstract
- In this study, the anticancer effect and improved safety for hypesensitivity reactions of docetaxel/hydroxypropyl-beta-cyclodextrin complex (DCX-CD) were investigated. The preparation of DCX-CD was confirmed by using differential scanning calorimetry, X-ray powder diffraction analysis, and scanning electron microscope. The anticancer activity was tested in human lung cancer A549 cell-transplanted mice and the hypersensitivity was tested in Beagle dogs after intravenous administration of DCX-CD, Taxotere, and their respective vehicles. In the hypersensitivity test, plasma histamine levels were determined using an ELISA method. Our results showed that DCX-CD was pharmacologically equivalent to Taxotere. Furthermore, DCX-CD did not cause the release of histamines or any significant symptoms associated with hypersensitivity. These results suggested that DCX-CD could be a promising alternative to Taxotere for cancer chemotherapy with reduced side effects.
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