Self-assembling β-glucan nanomedicine for the delivery of sirnaopen access
- Authors
- Lee, Kyungwoo; Min, Daejin; Choi, Yonghyun; Yoon, Semi; Jang, Jaehee; Hwang, Jangsun; Jeon, Hojeong; Cho, Yong Woo; Choi, Jonghoon
- Issue Date
- Nov-2020
- Publisher
- MDPI AG
- Keywords
- beta-glucan; self-assembly; nanomedicine; siRNA; gene delivery
- Citation
- Biomedicines, v.8, no.11, pp 1 - 11
- Pages
- 11
- Indexed
- SCIE
SCOPUS
- Journal Title
- Biomedicines
- Volume
- 8
- Number
- 11
- Start Page
- 1
- End Page
- 11
- URI
- https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/1833
- DOI
- 10.3390/biomedicines8110497
- ISSN
- 2227-9059
2227-9059
- Abstract
- We aimed to design and manufacture a transporter capable of delivering small interfering RNAs (siRNAs) into the skin without causing any damage. β-glucans are unique chiral polysaccharides with well-defined immunological properties and supramolecular wrapping ability. However, the chiral properties of these polymers have hardly been applied in drug delivery systems. In this study, β-glucan nanoparticles were designed and manufactured to deliver genetic material to the target cells. The β-glucan molecules were self-assembled with an siRNA into nanoparticles of 300–400 nm in diameter via a conformational transition process, in order to construct a gene delivery system. The assembled gene nanocarriers were associated with high gene-loading ability. The expression and efficiency of siRNA were verified after its delivery via β-glucan. Our results provide evidence that β-glucan nanoparticles can be effectively used to deliver siRNA into the cells. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
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Collections - COLLEGE OF ENGINEERING SCIENCES > DEPARTMENT OF MATERIALS SCIENCE AND CHEMICAL ENGINEERING > 1. Journal Articles
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