Highly sensitive non-enzymatic lactate biosensor driven by porous nanostructured nickel oxide
- Authors
- Kim, Sungjin; Yang, Won Sik; Kim, Hyun-Jong; Lee, Ho-Nyun; Park, Tae Joo; Seo, Seok-Jun; Park, Young Min
- Issue Date
- Dec-2019
- Publisher
- Pergamon Press Ltd.
- Keywords
- Lactate detection; Porous nickel oxide; Electrochemical sensor; Amperometric biosensor; Non-enzymatic biosensor
- Citation
- Ceramics International, v.45, no.17, pp.23370 - 23376
- Indexed
- SCIE
SCOPUS
- Journal Title
- Ceramics International
- Volume
- 45
- Number
- 17
- Start Page
- 23370
- End Page
- 23376
- URI
- https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/1982
- DOI
- 10.1016/j.ceramint.2019.08.037
- ISSN
- 0272-8842
- Abstract
- Lactate sensors are increasingly used for applications in sports and clinical medicine, but currently have several shortcomings including low sensitivity. We demonstrate a highly sensitive and selective non-enzymatic lactate sensor based on porous nickel oxide by sol-gel based inverse micelle method. The porosity and surface area of nickel oxide depending on the calcination temperature (250, 350, and 450 degrees C) were compared using electron microscopy and a Brunauer-Emmett-Teller (BET) surface area analyzer. Furthermore, we also compared the chemical state of Ni3+ in porous nickel oxides, which is known to be strongly engaged with electrocatalytic lactate detection, with different calcination temperature. The sensing characteristics were assessed using an amperometric response with a three-electrode system. Owing to a relatively large surface area and high Ni3+/Ni2+ ratio, NiO calcined at 250 degrees C, exhibit maximum sensitivity at 62.35 mu A/mM (cm(2)), and a minimum detection of limit of 27 mu M, although, it has large amount of organic residue because of low calcination temperature. In addition to its sensitivity, a porous nickel oxide electrode also displays good selectivity against other interferents such as L-ascorbic acid, uric acid, and dopamine, further supporting its potential as a non-enzymatic lactate sensor.
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