Protective Activity of Dendropanax Morbifera Against Cisplatin-Induced Acute Kidney Injury
- Authors
- Kim, Eun-Sun; Lee, Jong Soo; Akram, Muhammad; Kim, Kyeong-A; Shin, Young-Jun; Yu, Jong-Hyun; Bae, Ok-Nam
- Issue Date
- Mar-2015
- Publisher
- S. Karger AG
- Keywords
- Nephrotoxicity; Cisplatin; Acute kidney injury; Dendropanax morbifera
- Citation
- Kidney and Blood Pressure Research, v.40, no.1, pp.1 - 12
- Indexed
- SCIE
SCOPUS
- Journal Title
- Kidney and Blood Pressure Research
- Volume
- 40
- Number
- 1
- Start Page
- 1
- End Page
- 12
- URI
- https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/20998
- DOI
- 10.1159/000368466
- ISSN
- 1420-4096
- Abstract
- Background/Aims: Drug-induced acute kidney injury (AKI) has been a severe threat to hospitalized patients, raising the urgent needs to develop strategies to reduce AKI. We investigated the protective activity of Dendropanax morbifera (DP), a medicinal plant which has been widely used to treat infectious and pain diseases, on acute kidney injury (AKI) using cisplatin-induced nephropathic models. Methods: Both in vitro renal tubular cells (NRK-52E) and in vivo rat models were used to demonstrate the nephroprotective effect of DP. Results: Methanolic extract from DP significantly reduced cisplatin-induced toxicity in renal tubular cells. Through successive liquid extraction, the extract of DP was separated into n-hexane, CHCl3, EtOAc, n-BuOH, and H2O fractions. Among these, the CHCl3 fraction (DPCF) was found to be most potent. The protective activity of DPCF was found to be mediated through anti-oxidant, mitochondrial protective, and anti-apoptotic activities. In in vivo rat models of AKI, treatment with DPCF significantly reversed the cisplatin-induced increase in blood urea nitrogen and serum creatinine and histopathologic damage, recovered the level of anti-oxidant enzymes, and inhibited renal apoptosis. Conclusion: We demonstrated that DP extracts decreased cisplatin-induced renal toxicity, indicating its potential to ameliorate drug-associated acute kidney damage.
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