Hyaluronic acid-coated solid lipid nanoparticles for targeted delivery of vorinostat to CD44 overexpressing cancer cells
- Authors
- Tuan Hiep Tran; Choi, Ju Yeon; Ramasamy, Thiruganesh; Duy Hieu Truong; Chien Ngoc Nguyen; Choi, Han-Gon; Yong, Chul Soon; Kim, Jong Oh
- Issue Date
- Dec-2014
- Publisher
- ELSEVIER SCI LTD
- Keywords
- Vorinostat; Solid lipid nanoparticles; Hyaluronic acid; Chemotherapy; Targeting
- Citation
- CARBOHYDRATE POLYMERS, v.114, pp.407 - 415
- Indexed
- SCIE
SCOPUS
- Journal Title
- CARBOHYDRATE POLYMERS
- Volume
- 114
- Start Page
- 407
- End Page
- 415
- URI
- https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/21045
- DOI
- 10.1016/j.carbpol.2014.08.026
- ISSN
- 0144-8617
- Abstract
- Hyaluronic acid (HA)-decorated solid lipid nanoparticles (SLNs) were developed for tumor-targeted delivery of vorinostat (VRS), a histone deacetylase inhibitor. HA, a naturally occurring polysaccharide, which specifically binds to the CD44 receptor, was coated on a cationic lipid core through electrostatic interaction. After the optimization process, HA-coated VRS-loaded SLNs (HA-VRS-SLNs) were spherical, core-shell nanoparticles, with small size (similar to 100 nm), negative charge (similar to-9 mV), and narrow size distribution. In vitro release profile of HA-VRS-SLNs showed a typical bi-phasic pattern. In addition, the intracellular uptake of HA-VRS-SLNs was significantly enhanced in CD44 overexpressing cells, A549 and SCC-7 cells, but reduced when HA-VRS-SLNs were incubated with SCC-7 cells pretreated with HA or MCF-7 cells with low over-expressed CD44. Of particular importance, HA-VRS-SLNs were more cytotoxic than the free drug and VRS-SLNs in A549 and SCC-7 cells. In addition, HA shell provided longer blood circulation and reduced VRS clearance rate in rats, resulting in enhanced higher plasma concentration and bioavailability. These results clearly indicated the potential of the HA-functionalized lipid nanoparticle as a nano-sized drug formulation for chemotherapy. (C) 2014 Elsevier Ltd. All rights reserved.
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