A mouse polyomavirus-encoded microRNA targets the cellular apoptosis pathway through Smad2 inhibition
- Authors
- Sung, C.K.; Yim, H.; Andrews, E.; Benjamin, T.L.
- Issue Date
- Nov-2014
- Publisher
- Academic Press Inc.
- Keywords
- Mouse polyomavirus; MicroRNA; Apoptosis; Smad2 a cellular target; Animal infection
- Citation
- Virology, v.468, pp.57 - 62
- Indexed
- SCIE
SCOPUS
- Journal Title
- Virology
- Volume
- 468
- Start Page
- 57
- End Page
- 62
- URI
- https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/25449
- DOI
- 10.1016/j.virol.2014.07.052
- ISSN
- 0042-6822
- Abstract
- Some viruses and most eukaryotic cells have microRNAs that regulate the expression of many genes. Although many viral miRNAs have been identified, only a few have been included in in vivo functional studies. Here we show that a Py-encoded miRNA downregulates the expression of the pro-apoptotic factor Smad2, resulting in the suppression of the apoptosis pathway. To study the Py miRNA in an in vivo context, a miRNA-deficient mutant virus was created on the background of the LID virus strain which establishes a rapid and lethal infection in newborn mice. Apoptosis analysis on kidney tissues indicates that the pro-apoptotic pathway is targeted in the infected host as well. Suppression of apoptosis through targeting of Smad2 by the Py miRNA is expected to synergize with anti-apoptotic effects previously attributed to the polyoma tumor antigens in support of virus replication in the natural host. © 2014 Elsevier Inc.
- Files in This Item
-
Go to Link
- Appears in
Collections - COLLEGE OF PHARMACY > DEPARTMENT OF PHARMACY > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/25449)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.