Swimming exercise stimulates neuro-genesis in the subventricular zone via increase in synapsin i and nerve growth factor levels
- Authors
- Chae, Chang-hun; Jung, Sung-lim; An, Sang-hyun; Park, B-Y; Kim, Tae-woon; Wang, S-W; Kim, Jae-hyoo; Lee, H-C; Kim, Hyun-tae
- Issue Date
- 2014
- Publisher
- Instytut Sportu/Institute of Sport
- Keywords
- physical training; progenitor cells; olfactory bulb; neurotrophic factors; brain; rats
- Citation
- Biology of Sport, v.31, no.4, pp.309 - 314
- Indexed
- SCIE
SCOPUS
- Journal Title
- Biology of Sport
- Volume
- 31
- Number
- 4
- Start Page
- 309
- End Page
- 314
- URI
- https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/25889
- DOI
- 10.5604/20831862.1132130
- ISSN
- 0860-021X
- Abstract
- In this study, we investigated the effects of 8-weeks of swimming exercise on neurogenesis in the subventricular zone (SVZ) and on the levels of nerve growth factor (NGF) and synapsin I protein in the olfactory bulb (OB) of adult rats at a series of relevant time points (2 days, 1 week, 2 weeks, 4 weeks, 3 months, and 6 months). Ninety-six male Sprague Dawley rats were divided into 2 groups: (1) a control group (COG; n = 48, n = 8 for each time point) and (2) a swimming exercise group (SEG; total n = 48; n = 8 for each time point). SEG performed swimming exercise for 5 days per week over a period of 8 weeks. We found that the number of 5-bromo-2'-deoxyuridine-5'-monophosphate (BrdU)- and doublecortin (DCX)-positive cells was significantly higher in SEG than in COG at all time points (Day 2, Week 1, Week 2, Week 4, Month 3, and Month 6; p < 0.001). Furthermore, NGF and synapsin I protein levels were significantly higher in SEG on Day 2, and Weeks 1, 2, and 4 than in COG (p < 0.05 for each time point). Our findings suggest that regular swimming exercise in adult rats increases neurogenesis, neuronal survival, and neuronal maintenance in the SVZ; furthermore, swimming exercise increases the levels of NGF and synapsin I in the OB.
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