Development of docetaxel-loaded solid self-nanoemulsifying drug delivery system (SNEDDS) for enhanced chemotherapeutic effect
- Authors
- Seo, Youn Gee; Kim, Dae Hwan; Ramasamy, Thiruganesh; Kim, Jeong Hwan; Marasini, Nirmal; Oh, Yu-Kyoung; Kim, Dong-Wuk; Kim, Jin Ki; Yong, Chul Soon; Kim, Jong Oh; Choi, Han-Gon
- Issue Date
- Aug-2013
- Publisher
- ELSEVIER
- Keywords
- Anti-tumor efficacy; Bioavailability; Docetaxel; Self-nanoemulsifying drug delivery systems; Toxicity
- Citation
- INTERNATIONAL JOURNAL OF PHARMACEUTICS, v.452, no.1-2, pp.412 - 420
- Indexed
- SCIE
SCOPUS
- Journal Title
- INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Volume
- 452
- Number
- 1-2
- Start Page
- 412
- End Page
- 420
- URI
- https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/27173
- DOI
- 10.1016/j.ijpharm.2013.05.034
- ISSN
- 0378-5173
- Abstract
- The main purpose of this study was to investigate the potential of self-nano-emulsifying drug delivery system (SNEDDS) in improving the bioavailability of docetaxel (DCT) and its chemotherapeutic effect. The DCT-loaded SNEDDS was prepared by employing rational blends of capryol 90, labrasol, and transcutol HP using ternary phase diagram. The liquid nano-emulsion was spray-dried into solid SNEDDS (D-SNEDDS) using an inert porous carrier, colloidal silica. The optimized formulation was characterized in terms of physico-chemical and pharmacokinetic parameters. Furthermore, anti-tumor efficacy of D-SNEDDS was compared with commercial marketed product, Taxotere (R). The various compositions of SNEDDS were screened and found optimal at a volume ratio of 10/75/15 for capryol 90, labrasol, and transcutol HP, respectively. We observed a high oral bioavailability of 17% DCT for D-SNEDDS than compared to only 2.6% for pure DCT solution. Notably, D-SNEDDS exhibited an augmented anti-tumor efficacy with a reduced toxicity profile when compared with intravenously administered Taxotere (R), the commercialized formulation of DCT. Taken together, D-SNEDDS could be a potential candidate for an oral dosage form of DCT with enhanced antitumor activity and reduced toxicity. (C) 2013 Elsevier B. V. All rights reserved.
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