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Vasorelaxant Prenylated Flavonoids from the Roots of Sophora flavescens
- Issue Date
- Feb-2013
- Publisher
- TAYLOR & FRANCIS LTD
- Keywords
- vasorelaxation activity; Sophora flavescens; prenylated flavonoid; kushenol N; 5-methylsophoraflavanone B
- Citation
- BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, v.77, no.2, pp 395 - 397
- Pages
- 3
- Indexed
- SCI
SCIE
SCOPUS
- Journal Title
- BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
- Volume
- 77
- Number
- 2
- Start Page
- 395
- End Page
- 397
- ISSN
- 0916-8451
1347-6947
- Abstract
- Bioassay-guided fractionation of the methanol extract from the root of Sophora flaivscens led to the isolation of eight known prenylated flavonoids responsible for the vasorelaxation activity in porcine coronary arteries. Among them, kushenol N and 5-methylsophoraflavanone B strongly induced the relaxation of porcine coronary arteries with respective ED50 values of 8.6 and 12.4 mu m. This activity and the results of a high-performance liquid chromatographic analysis suggest that kushenol N and 5-methylsophoraflavanone B could be active markers in the S. flavescens extract for vasorelaxation activity.
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Related Researcher
- Kim, Chul Young
- COLLEGE OF PHARMACY (DEPARTMENT OF PHARMACY)