Study of highly selective and sensitive microarray structure based on hydrophilic/hydrophobic SAMs (Self Assembled Monolayers)
- Authors
- Lee, Jung hwan; Cho, Si hyeong; Lim, Hyun woo; Kim, Sungwoo; Busnaina, Ahmed.A.; Lee, Hea yeon; Park, Jin-Goo
- Issue Date
- Dec-2012
- Publisher
- Scitec Publications Ltd.
- Keywords
- Fluorescence analysis; Microarray; SAM(Self Assembled Monolayer)
- Citation
- Solid State Phenomena, v.195, pp 82 - 85
- Pages
- 4
- Indexed
- SCIE
SCOPUS
- Journal Title
- Solid State Phenomena
- Volume
- 195
- Start Page
- 82
- End Page
- 85
- URI
- https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/30544
- DOI
- 10.4028/www.scientific.net/SSP.195.82
- ISSN
- 1012-0394
1662-9779
- Abstract
- A microarray-based immunoassay requires only small volume of the sample in each array spot, which leads to faster completion of the immunoreactions than with an ELISA (enzyme-linked immunosorbent assay) [. However, this method still has some technical limitations such as poor signal sensitivity, poor detection limit, large sample consumption, high evaporation rate, coffee stain effect, low signal/noise ratio (SNR) and poor quality images. Recently, SAM (Self-Assembled Monolayer) method was extensively researched for control the surface wettability [. Especially, hydrophobic SAM functionalizations which has low surface energy are possible to prevent sample evaporation [ and to achieve anti-biofouling on them. Therefore, an introduction of hydrophobic SAM would enhance the detection sensitivity on bio array chip [4]. In this work, we fabricated a highly selective and sensitive pre-patterned microarray structure by using MEMS (Micro-Electro-Mechanical-System) process and hydrophilic/hydrophobic SAMs with various precursors.
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