The Evaluation of CP-001 (a Standardized Herbal Mixture of Houttuynia cordata, Rehmannia glutinosa, Betula platyphylla, and Rubus coreanus) for Cytochrome P450-Related Herb-Drug Interactions
- Authors
- Yoo, Hye Hyun; Kim, Sun-A; Kim, In Sook; Ko, Seong-Gyu
- Issue Date
- Jul-2013
- Publisher
- Oxford University Press
- Keywords
- INFLAMMATION
- Citation
- Evidence-based Complementary and Alternative Medicine, v.2013, pp.1 - 5
- Indexed
- SCIE
SCOPUS
- Journal Title
- Evidence-based Complementary and Alternative Medicine
- Volume
- 2013
- Start Page
- 1
- End Page
- 5
- URI
- https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/30962
- DOI
- 10.1155/2013/824270
- ISSN
- 1741-427X
- Abstract
- In the present study, the effect of CP-001, a standardized herbal mixture of Houttuynia cordata, Rehmannia glutinosa, Betula platyphylla, and Rubus coreanus, on cytochrome P450 (CYP) enzyme-mediated drug metabolism was investigated in vitro to evaluate the potential for herb-drug interactions. CP-001 was tested at concentrations of 1, 3, 10, 30, and 100 mu g/mL. A CYP-specific substrate mixture was incubated with CP-001 in human liver microsomes, and the metabolites generated by each CYP-specific metabolic reaction were measured by liquid chromatography-tandem mass spectrometry. CP-001 seemed to slightly inhibit some CYP isozymes, but the IC50 values for all CYP isozymes were greater than 100 mu g/mL. Furthermore, CP-001 did not exhibit time-dependent CYP inhibitory activities, indicating that it does not act as a mechanism-based inactivator of CYP enzymes. In conclusion, the effects of CP-001 on CYP isozyme activities were negligible at the concentrations tested. Therefore, the likelihood of herbal mixture-drug interaction is considered minimal.
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