Flurbiprofen-loaded nanoparticles prepared with polyvinylpyrrolidone using Shirasu porous glass membranes and a spray-drying technique: nano-sized formation and improved bioavailabilityopen access
- Authors
- Oh, Dong Hoon; Din, Fakhar Ud; Kim, Dong Wuk; Kim, Jong Oh; Yong, Chul Soon; Choi, Han-Gon
- Issue Date
- Feb-2013
- Publisher
- INFORMA HEALTHCARE
- Keywords
- Shirasu porous glass membrane; spray drying; nanoparticle; flurbiprofen; polyvinylpyrrolidone
- Citation
- JOURNAL OF MICROENCAPSULATION, v.30, no.7, pp.674 - 680
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF MICROENCAPSULATION
- Volume
- 30
- Number
- 7
- Start Page
- 674
- End Page
- 680
- URI
- https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/30967
- DOI
- 10.3109/02652048.2013.774447
- ISSN
- 0265-2048
- Abstract
- A unique flurbiprofen-loaded nanoemulsion was listed earlier using a Shirasu porous glass (SPG) membrane emulsification technique, which gave constant emulsion droplets with a thin size distribution. In this study, a flurbiprofen-loaded nanoemulsion was developed further into a solid form using polyvinylpyrrolidone (PVP) as a carrier by a spray-drying technique. The flurbiprofen-loaded nanoparticles with a weight ratio of flurbiprofen/PVP/surfactant mixture of 1/8/2 were connected with about 130 000-fold enhanced drug solubility and had a mean size of about 70 nm. In these nanoparticles, flurbiprofen was found in an altered amorphous state. Additionally, the nanoparticles gave significantly shorter T-max, and greater AUC and C-max compared to the commercially available product. Specially, the AUC of the drug from the nanoparticles was about 10-fold greater compared to the commercially available product. Therefore, these flurbiprofen-loaded nanoparticles can be convenient for distributing a poorly water-soluble flurbiprofen with improved bioavailability using uniform nano-sized particles.
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