Fabrication of drug-loaded polymer microparticles with arbitrary geometries using a piezoelectric inkjet printing system
- Authors
- Lee, Byung Kook; Yun, Yeon Hee; Choi, Ji Suk; Choi, Young Chan; Kim, Jae Dong; Cho, Yong Woo
- Issue Date
- May-2012
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- Inkjet printing; Microparticles; Geometry; Drug release; In vitro cytotoxicity
- Citation
- INTERNATIONAL JOURNAL OF PHARMACEUTICS, v.427, no.2, pp.305 - 310
- Indexed
- SCIE
SCOPUS
- Journal Title
- INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Volume
- 427
- Number
- 2
- Start Page
- 305
- End Page
- 310
- URI
- https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/33004
- DOI
- 10.1016/j.ijpharm.2012.02.011
- ISSN
- 0378-5173
- Abstract
- Carrier geometry is a key parameter of drug delivery systems and has significant impact on the drug release rate and interaction with cells and tissues. Here we present a piezoelectric inkjet printing system as a simple and convenient approach for fabrication of drug-loaded polymer microparticles with well-defined and controlled shapes. The physical properties of paclitaxel (PTX)-loaded poly(lactic-co-glycolic acid) (PLGA) inks, such as volatility, viscosity and surface tension, were optimized for piezoelectric inkjet printing, and PTX-loaded PLGA microparticles were fabricated with various geometries, such as circles, grids, honeycombs, and rings. The resulting microparticles with 10% (w/w) PTX exhibited a fairly homogeneous shape and size. The microparticle fabrication by piezoelectric inkjet printing was precise, reproducible, and highly favorable for mass production. The microparticles exhibited a biphasic release profile with an initial burst due to diffusion and a subsequent, slow second phase due to degradation of PLGA. The release rate was dependent on the geometry, mainly the surface area, with a descending rate order of honeycomb > grid, ring > circle. The PTX-loaded microparticles showed a comparable activity in inhibiting the growth of HeLa cells. Our results demonstrate that a piezoelectric inkjet printing system would provide a new approach for large-scale manufacturing of drug carriers with a desired geometry. (C) 2012 Elsevier B.V. All rights reserved.
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