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Protective effects of cleavage agents on INS-1 cells against h-IAPP-induced apoptosis
- Issue Date
- Jan-2012
- Publisher
- Royal Society of Chemistry
- Citation
- Chemical Communications, v.48, no.4, pp.588 - 590
- Indexed
- SCIE
SCOPUS
- Journal Title
- Chemical Communications
- Volume
- 48
- Number
- 4
- Start Page
- 588
- End Page
- 590
- ISSN
- 1359-7345
- Abstract
- Cleavage agents showed cleavage yields as much as 9-14%, which does not sufficiently support the agents' protection of beta-cells from the cytotoxicity of h-IAPP. INS-1 cell tests were carried out to better understand the potential of using these cleavage agents as drug candidates. This study provides the firm basis for clinical applicability of these cleavage agents.
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Related Researcher
- Chae, Pil Seok
- ERICA 공학대학 (DEPARTMENT OF BIONANO ENGINEERING)