The Role of the Lignan Constituents in the Effect of Schisandra chinensis Fruit Extract on Penile Erectionopen access
- Authors
- Kim, Hye Kyung; Bak, Yun Ok; Choi, Bo Ram; Zhao, Chen; Lee, Hee Ju; Kim, Chul Young; Lee, Sung Won; Jeon, Ju Hong; Park, Jong Kwan
- Issue Date
- Dec-2011
- Publisher
- WILEY-BLACKWELL
- Keywords
- Schisandra chinensis; penile corpus cavernosum; sildenafil citrate; schisandrol A; schisandrol B
- Citation
- PHYTOTHERAPY RESEARCH, v.25, no.12, pp.1776 - 1782
- Indexed
- SCIE
SCOPUS
- Journal Title
- PHYTOTHERAPY RESEARCH
- Volume
- 25
- Number
- 12
- Start Page
- 1776
- End Page
- 1782
- URI
- https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/36384
- DOI
- 10.1002/ptr.3486
- ISSN
- 0951-418X
- Abstract
- The effect of the ethanol extract and active components of the fruit of Schisandra chinensis was evaluated on rabbit penile corpus cavernosum (PCC). PCC, pre-contracted with 10(-5) M phenylephrine (Phe), was treated with extracts of S. chinensis at five different compositions of ethanol and water (95%, 70%, 50%, 30% and ethanol/water [v/v]) and three fractions (0.1, 0.5, 1 and 2 mg/mL). The effect of the extracts and active lignans (schisandrol A and schisandrol B) from S. chinensis on sildenafil citrate pre-incubated PCC was also evaluated. The PCC relaxation induced by the 95% ethanol extraction and the n-hexane fraction was concentration-dependent and the ethanol extract enhanced sildenafil citrate-induced PCC relaxation. The active components of S. chinensis (schisandrol A and schisandrol B) significantly enhanced sildenafil citrate-induced relaxation >2-fold; schisandrol A had the highest relaxant effect on sildenafil citrate pre-incubated PCC. The lignans, schisandrol A and schisandrol B, isolated from the fruits of S. chinensis enhanced sildenafil citrate-induced relaxation and may have synergistic action in patients who do not completely respond to sildenafil. Copyright (C) 2011 John Wiley & Sons, Ltd.
- Files in This Item
-
Go to Link
- Appears in
Collections - COLLEGE OF PHARMACY > DEPARTMENT OF PHARMACY > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.