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Synthesis and Biological Evaluation of 1-Heteroarylmethyl 1,4-Diazepanes Derivatives as Potential T-type Calcium Channel Blockers
- Authors
- Ullapu, Punna Reddy; Ku, Su Jin; Choi, Yeon Hee; Park, Jiyeon; Han, So-Yeop; Baek, Du Jong; Lee, Jaekyun; Pae, Ae Nim; Min, Sun-Joon; Cho, Yong Seo
- Issue Date
- Aug-2011
- Publisher
- 대한화학회
- Keywords
- T-type calcium channel blockers; 1,4-Diazepanes; Heteroaromatic compounds; FDSS6000 assay; Patch-clamp assay
- Citation
- Bulletin of the Korean Chemical Society, v.32, no.8, pp.3063 - 3073
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- Bulletin of the Korean Chemical Society
- Volume
- 32
- Number
- 8
- Start Page
- 3063
- End Page
- 3073
- ISSN
- 0253-2964
- Abstract
- The synthesis and biological evaluation of 1-heteroarylmethyl 1,4-diazepane derivatives as potential T-type calcium channel blockers is described. In this study, we have identified the compound 211 exhibiting the most potent T-type calcium channel blocking activity with IC(50) value of 0.20 mu M, which is superior to that of mibefradil.
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Related Researcher
- Min, Sun Joon
- ERICA 공학대학 (ERICA 에너지바이오학과)