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Identfication of phase I and phase II metabolites of hesperetin in rat liver microsomes by liquid chromatography-electrospray ionization-tandem mass spectrometryopen access
- Issue Date
- Mar-2011
- Publisher
- Korean Society for Mass Spectrometry
- Keywords
- Hesperetin; In vitro metabolism; LC/MS; Rat liver microsomes
- Citation
- Mass Spectrometry Letters, v.2, no.1, pp.20 - 23
- Indexed
- SCOPUS
- Journal Title
- Mass Spectrometry Letters
- Volume
- 2
- Number
- 1
- Start Page
- 20
- End Page
- 23
- ISSN
- 2233-4203
- Abstract
- The purpose of this study is to investigate the in vitro metabolism of hesperetin, a bioflavonoid. Hesperetin was incubated with rat liver microsomes in the presence of NADPH and UDP-glucuronic acid for 30 min. The reaction mixture was analyzed by liquid chromatography-ion trap mass spectrometer and the chemical structures of hesperetin metabolites were characterzed based on their MS/MS spectra. As a result, a total of five metabolites were detected in rat liver microsomes. The metabolites were identified as a demethylated metabolite (eriodictyol), two hesperetin glucuronides, and two eriodictyol glucuronides.
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Related Researcher
- Yoo, Hye Hyun
- COLLEGE OF PHARMACY (DEPARTMENT OF PHARMACY)