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Synthesis and biological evaluation of 1,4-diazepane derivatives as T-type calcium channel blockers
- Authors
- Gu, Su Jin; Lee, Jae Kyun; Pae, Ae Nim; Chung, Hye Jin; Rhim, Hyewon; Han, So Yeob; Min, Sun-Joon; Cho, Yong Seo
- Issue Date
- May-2010
- Publisher
- Pergamon Press Ltd.
- Keywords
- T-type calcium channel blockers; 1,4-Diazepane; Pharmacokinetics
- Citation
- Bioorganic and Medicinal Chemistry Letters, v.20, no.9, pp 2705 - 2708
- Pages
- 4
- Indexed
- SCI
SCIE
SCOPUS
- Journal Title
- Bioorganic and Medicinal Chemistry Letters
- Volume
- 20
- Number
- 9
- Start Page
- 2705
- End Page
- 2708
- ISSN
- 0960-894X
1464-3405
- Abstract
- We have synthesized and biologically evaluated 1,4-diazepane derivatives as T-type calcium channel blockers. In this study, we discovered compound 4s, a potential T-type calcium channel blocker with good selectivity over hERG and N-type calcium channels. In addition, it exhibited favorable pharmacokinetic characteristics for further investigation of T-type calcium channel related diseases. (C) 2010 Elsevier Ltd. All rights reserved.
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Related Researcher
- Min, Sun Joon
- COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY (DEPARTMENT OF CHEMICAL AND MOLECULAR ENGINEERING)