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Inhibitory Effects of Dicaffeoylquinic Acids from Artemisia dubia on Aldo-keto Reductase Family 1B10
- Authors
- Lee, Hee Ju; Lee, Joo Young; Kim, Sang Min; Nho, Chu Won; Jung, Sang Hoon; Song, Dae-Geun; Kim, Chul Young; Pan, Cheol-Ho
- Issue Date
- Dec-2010
- Publisher
- 한국응용생명화학회
- Keywords
- AKR1B10; aldose reductase-like; anticancer; DCQA; dicaffeoylquinic acid; Artemisia dubia
- Citation
- Applied Biological Chemistry, v.53, no.6, pp 826 - 830
- Pages
- 5
- Indexed
- KCI
- Journal Title
- Applied Biological Chemistry
- Volume
- 53
- Number
- 6
- Start Page
- 826
- End Page
- 830
- ISSN
- 2468-0834
2468-0842
- Abstract
- The ethyl acetate fraction of Artemisia dubia showed a potent inhibitory activity on recombinant human AKR1B10 (rh AKR1B10). Due to its potency, subsequent purification of ethyl acetate fraction led to seven compounds including five dicaffeoylquinic acid (DCQA) derivatives. Compounds were identified as 3,4-dihydroxybenzoic acid (1), quercetin 3-O-β-glucose (2), 3,4- DCQA (3), 3,5-DCQA (4), 4,5-DCQA (5), 3,5-DCQA methyl ester (6), and 4,5-DCQA methyl ester (7). A series of DCQA derivatives (3-7) showed inhibitory activity on rhAKR1B10 in the range of IC50 1.24-2.29 μM, whereas 3,4-dihydroxybenzoic acid and quercetin 3-O-β-glucose showed no inhibitory activity on rhAKR1B10.
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Related Researcher
- Kim, Chul Young
- COLLEGE OF PHARMACY (DEPARTMENT OF PHARMACY)