Biomarker analysis of rat livers exposed to different toxic pollutants (VOCs and PAHs) using an antibody array
- Authors
- Kim, Eung-Yoon; Lee, Mi-Young; Hwang, Seung Yong; Kang, In-Cheol
- Issue Date
- Sep-2010
- Publisher
- 한국바이오칩학회
- Keywords
- Antibody array; Biomarker assay; Environmental pollutants; PAHs; Protein chip; VOCs
- Citation
- BioChip Journal, v.4, no.3, pp.173 - 178
- Indexed
- SCIE
SCOPUS
KCI
OTHER
- Journal Title
- BioChip Journal
- Volume
- 4
- Number
- 3
- Start Page
- 173
- End Page
- 178
- URI
- https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/40414
- DOI
- 10.1007/s13206-010-4302-x
- ISSN
- 1976-0280
- Abstract
- We have developed an antibody microarray chip for biomarker analysis in rat livers exposed to five different toxic pollutants: volatile organic compounds (VOCs), dichloromethane, ethylbenzene, and trichloroethylene; and polycyclic aromatic hydrocarbons (PAHs), benzoanthracene and phenanthrene. The antibody chip consisted of antibodies against different biomarkers: alpha-2 μ globulin, glutathione S transferase (GST)-α, Hemoglobin β, and Phenylalanine hydroxylase. VOC- and PAH-treated rat livers showed differential expression patterns of the biomarker proteins. These results demonstrate that a protein chipbased antibody array is useful for the analysis of biomarkers induced by environmental toxic pollutants and can be a powerful tool to study the mechanisms of pollutants in biological samples. © The Korean BioChip Society and Springer 2010.
- Files in This Item
-
Go to Link
- Appears in
Collections - COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY > ERICA 의약생명과학과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/40414)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.