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HY253, a novel compound isolated from Aralia continentalis, induces apoptosis via cytochrome c-mediated intrinsic pathway in HeLa cells
- Authors
- Oh, Ha Lim; Lim, Haeyoung; Park, Younghee; Lim, Yoongho; Koh, Hyun Chul; Cho, Youl-Hee; Lee, Chul-Hoon
- Issue Date
- Feb-2009
- Publisher
- Pergamon Press Ltd.
- Keywords
- Aralia continentalis; Apoptotic induction; Cytochrome c; HeLa cells
- Citation
- Bioorganic & Medicinal Chemistry Letters, v.19, no.3, pp 797 - 799
- Pages
- 3
- Indexed
- SCIE
SCOPUS
- Journal Title
- Bioorganic & Medicinal Chemistry Letters
- Volume
- 19
- Number
- 3
- Start Page
- 797
- End Page
- 799
- ISSN
- 0960-894X
1464-3405
- Abstract
- This study was aimed to elucidate the novel structure of HY253 isolated from the roots of Aralia continentalis and to evaluate its detailed mechanisms on apoptotic induction in HY253-treated HeLa cells. The structure of HY253 was elucidated based on the interpretation of the NMR spectra, as 7,8a-divinyl-2,4a,4b,5,6,7,8,8a, 9,9a-decahydro-1H-fluorene-2,4a,4b,9a-tetraol. The TUNEL assay using flow cytometer revealed an appreciable apoptotic induction in HeLa cells treated with 100 mu M of HY253 for 48 h. This apoptotic induction is associated with cytochrome c release from mitochondria, via up-regulation of pro-apoptotic Bcl-2 proteins, such as Bax and Bak, which, in turn, resulted in the activation of caspase-8, -9 and -3, and the cleavage of poly(ADP-ribose) polymerase (PARP). (C) 2008 Elsevier Ltd. All rights reserved.
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