Detailed Information
Cited 0 time in 
Cited 0 time in 
Cited 0 time in
Metadata Downloads
Cleavage agents for soluble oligomers of amyloid beta peptides
- Authors
- Suh, Junghun; Yoo, Sang Ho; Kim, Min Gyum; Jeong, Keunhong; Ahn, Jae Young; Kim, Myoung-Soon; Chae, Pil Seok; Lee, Tae Yeon; Lee, Jaehwa; Lee, Jeongkuk; Jang, Yun Ah; Ko, Eun Hwa
- Issue Date
- 2007
- Publisher
- John Wiley & Sons Ltd.
- Keywords
- Alzheimer' s disease; amyloid beta peptides; combinatorial chemistry; drug design; peptide cleavage
- Citation
- Angewandte Chemie - International Edition, v.46, no.37, pp.7064 - 7067
- Indexed
- SCIE
SCOPUS
- Journal Title
- Angewandte Chemie - International Edition
- Volume
- 46
- Number
- 37
- Start Page
- 7064
- End Page
- 7067
- ISSN
- 1433-7851
- Abstract
- (Chemical Equation Presented) Clearing the mind: Peptide-cleaving agents for amyloid β-42 (Aβ42) oligomers (see scheme), the intermediate neurotoxic species in the pathology of Alzheimer's disease, have been obtained from a combinatorial library built using the CoIII complex of 1,4,7,10-tetraazacyclododecane as the reaction center. Effective cleavage of the Aβ42 oligomers occurs at submicromolar concentrations of the agents. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
- Files in This Item
- Go to Link
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
Related Researcher
- Chae, Pil Seok
- ERICA 공학대학 (DEPARTMENT OF BIONANO ENGINEERING)