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Total Synthesis and Biological Evaluation of Sericetin for Protection against Cisplatin-Induced Acute Kidney Injury
- Issue Date
- Dec-2018
- Publisher
- AMER CHEMICAL SOC
- Keywords
- PRENYLATED FLAVONOIDS; INDUCED NEPHROTOXICITY; OXIDATIVE STRESS; MACAKURZIN C; CELL-DEATH; IN-VITRO; INFLAMMATION; INHIBITION; MECHANISMS; APOPTOSIS
- Citation
- JOURNAL OF NATURAL PRODUCTS, v.81, no.12, pp.2647 - 2653
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF NATURAL PRODUCTS
- Volume
- 81
- Number
- 12
- Start Page
- 2647
- End Page
- 2653
- ISSN
- 0163-3864
- Abstract
- A concise synthesis of sericetin (1) was performed in four steps from readily available 3-O-benzylgalangin (4), featuring electrocyclization to produce the tricyclic core and a sequential aromatic Claisen/Cope rearrangement to incorporate the 8-prenyl group of 1. In addition, the therapeutic potential of sericetin (1), isosericetin (2), and three prenylated tetracyclic synthetic intermediates (11, 12, and 14) against cisplatin-induced nephrotoxicity using renal tubular cells were evaluated. Compound 14 showed therapeutic potential against cisplatin-induced kidney damage.
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Related Researcher
- Bae, Ok Nam
- COLLEGE OF PHARMACY (DEPARTMENT OF PHARMACY)