Biocompatible and biodegradable fibrinogen microspheres for tumor-targeted doxorubicin delivery
- Authors
- Joo, Jae Yeon; Park, Gilyong; An, Seong Soo A.
- Issue Date
- 2015
- Publisher
- DOVE MEDICAL PRESS LTD
- Keywords
- biocompatibility; anti-cancer drug; micro-structure; cytotoxicity; bio-conjugation; tumor targeting
- Citation
- INTERNATIONAL JOURNAL OF NANOMEDICINE, v.10, pp.101 - 111
- Journal Title
- INTERNATIONAL JOURNAL OF NANOMEDICINE
- Volume
- 10
- Start Page
- 101
- End Page
- 111
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/11977
- DOI
- 10.2147/IJN.S88381
- ISSN
- 1178-2013
- Abstract
- In the development of effective drug delivery carriers, many researchers have focused on the usage of nontoxic and biocompatible materials and surface modification with targeting molecules for tumor-specific drug delivery. Fibrinogen (Fbg), an abundant glycoprotein in plasma, could be a potential candidate for developing drug carriers because of its biocompatibility and tumor-targeting property via arginine-glycine-aspartate (RGD) peptide sequences. Doxorubicin (DOX), a chemotherapeutic agent, was covalently conjugated to Fbg, and the microspheres were prepared. Acid-labile and non-cleavable linkers were used for the conjugation of DOX to Fbg, resulting in an acid-triggered drug release under a mild acidic condition and a slow-controlled drug release, respectively. In vitro cytotoxicity tests confirmed low cytotoxicity in normal cells and high antitumor effect toward cancer cells. In addition, it was discovered that a longer linker could make the binding of cells to Fbg drug carriers easier. Therefore, DOX-linker-Fbg microspheres could be a suitable drug carrier for safer and effective drug delivery.
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