Measurement of creatinine in human plasma using a functional porous polymer structure sensing motif
- Authors
- Nanda, Sitansu Sekhar; An, Seong Soo A.; Yi, Dong Kee
- Issue Date
- 2015
- Publisher
- DOVE MEDICAL PRESS LTD
- Keywords
- PLGA; FPPS; creatinine; blood; diagnosis
- Citation
- INTERNATIONAL JOURNAL OF NANOMEDICINE, v.10, pp.93 - 99
- Journal Title
- INTERNATIONAL JOURNAL OF NANOMEDICINE
- Volume
- 10
- Start Page
- 93
- End Page
- 99
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/11978
- DOI
- 10.2147/IJN.S88378
- ISSN
- 1178-2013
- Abstract
- In this study, a new method for detecting creatinine was developed. This novel sensor comprised of two ionic liquids, poly-lactic-co-glycolic acid (PLGA) and 1-butyl-3-methylimidazolium (BMIM) chloride, in the presence of 2',7'-dichlorofluorescein diacetate (DCFH-DA). PLGA and BMIM chloride formed a functional porous polymer structure (FPPS)-like structure. Creatinine within the FPPS rapidly hydrolyzed and released OH-, which in turn converted DCFH-DA to DCFH, developing an intense green color or green fluorescence. The conversion of DCFH to DCF+ resulted in swelling of FPPS and increased solubility. This DCF+ based sensor could detect creatinine levels with detection limit of 5 mu M and also measure the creatinine in blood. This novel method could be used in diagnostic applications for monitoring individuals with renal dysfunction.
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