In Vivo and In Vitro Study of Immunostimulation by Leuconostoc lactis-Produced Gluco-Oligosaccharides
- Authors
- Lee, Sulhee; Song, In Ho; Park, Young-Seo
- Issue Date
- Nov-2019
- Publisher
- MDPI
- Keywords
- oligosaccharides; immunostimulation; MAPK signaling pathway; phagocytosis; cyclophosphamide
- Citation
- MOLECULES, v.24, no.21
- Journal Title
- MOLECULES
- Volume
- 24
- Number
- 21
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/17993
- DOI
- 10.3390/molecules24213994
- ISSN
- 1420-3049
- Abstract
- Glycosyltransferase-producing Leuconostoc lactis CCK940 produces CCK- oligosaccharides, gluco-oligosaccharide molecules, using sucrose and maltose as donor and acceptor molecules, respectively. In this study, the immunostimulatory activities of CCK-oligosaccharides on RAW264.7 macrophages and BALB/c mice were evaluated. CCK-oligosaccharides induced the expression of phosphorylated-p38, extracellular-signal-regulated kinase (ERK), and c-Jun N-terminal kinase (JNK) and upregulation of phagocytic activity in RAW264.7 macrophages, suggesting their involvement in mitogen-activated protein kinase (MAPK) signaling pathway and phagocytosis. When CCK-oligosaccharides were administered to mice intraperitoneally injected with cyclophosphamide (CY), spleen indices and expressions of interleukin (IL)-6, IL-10, and tumor necrosis factor-alpha increased, compared with those in only CY-treated group. These findings suggest that CCK-oligosaccharides can be used as an effective immunostimulating agent.
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Collections - 바이오나노대학 > 식품생물공학과 > 1. Journal Articles
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