Efficacy and Safety of Sinetrol-XPur on Weight and Body Fat Reduction in Overweight or Obese Adults: A 12-Week, Randomized, Double-Blind, Parallel, Placebo-Controlled Trial
- Authors
- Park, Seon-Joo; Sharma, Anshul; Bae, Mun Hyoung; Sung, Ha Chang; Kim, Nam Ki; Sung, Eunju; Lee, Hae-Jeung
- Issue Date
- Mar-2020
- Publisher
- MARY ANN LIEBERT, INC
- Keywords
- body fat mass; body mass index; bodyweight; obesity; Sinetrol-XPur
- Citation
- JOURNAL OF MEDICINAL FOOD, v.23, no.3, pp.335 - 342
- Journal Title
- JOURNAL OF MEDICINAL FOOD
- Volume
- 23
- Number
- 3
- Start Page
- 335
- End Page
- 342
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/26460
- DOI
- 10.1089/jmf.2019.4649
- ISSN
- 1096-620X
- Abstract
- This study investigated the effect of Sinetrol-XPur on weight and body fat reduction in overweight or obese Korean participants. Among 100 overweight or obese participants enrolled in a 12-week randomized, double-blinded, controlled study, 86 participants completed the trial. Participants took either two Sinetrol-XPur tablets (450 mg per tablet) or two placebo tablets once a day. Bodyweight, body fat percentage, body mass index (BMI), body fat mass, waist circumference, and various safety parameters were measured. After the 12-week intervention, a significant reduction was observed in the body fat mass (P = .030) by dual-energy X-ray absorptiometry (DEXA), body weight (P = .002), and BMI (P = .002) compared to the placebo. Body fat percentage (P = .007) by DEXA showed a significant reduction in the Sinetrol-XPur group, but no difference compared to the control group. Abdominal metabolic risks by computed tomography and blood biochemistry analysis were significantly decreased in the Sinetrol-XPur group, but there were no differences between the Sinetrol-XPur and placebo groups. Safety profiles were not different between the two groups. These results suggested that Sinetrol-XPur significantly reduced body weight, body fat mass, and BMI in obese Korean subjects, which confirms the antiobesity effect of Sinetrol-XPur in the Korean population.
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