Structural analysis and prebiotic activity of exopolysaccharide produced by probiotic strain Bifidobacterium bifidum EPS DA-LAIM
- Authors
- Kang, Min Joo; Jeong, Huijin; Kim, Suin; Shin, Jaein; Song, Youngbo; Lee, Byung-Hoo; Park, Hyoung-Geun; Lee, Tae-Ho; Jiang, Hai-Hua; Han, Young-Sun; Lee, Bong-Gyeong; Lee, Ho-Jin; Park, Min-Ju; Park, Young-Seo
- Issue Date
- Mar-2023
- Publisher
- KOREAN SOCIETY FOOD SCIENCE & TECHNOLOGY-KOSFOST
- Keywords
- Exopolysaccharide; Bifidobacterium bifidum; Prebiotics; Probiotics; Immunostimulatory activity
- Citation
- FOOD SCIENCE AND BIOTECHNOLOGY, v.32, no.4, pp.517 - 529
- Journal Title
- FOOD SCIENCE AND BIOTECHNOLOGY
- Volume
- 32
- Number
- 4
- Start Page
- 517
- End Page
- 529
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/87418
- DOI
- 10.1007/s10068-022-01213-w
- ISSN
- 1226-7708
- Abstract
- Exopolysaccharide (EPS)-producing Bifidobacterium bifidum EPS DA-LAIM was isolated from healthy human feces, the structure of purified EPS from the strain was analyzed, and its prebiotic activity was evaluated. The EPS from B. bifidum EPS DA-LAIM is a glucomannan-type heteropolysaccharide with a molecular weight of 407-1007 kDa, and its structure comprises 2-mannosyl, 6-mannosyl, and 2,6-mannosyl residues. The purified EPS promoted the growth of representative lactic acid bacteria and bifidobacterial strains. Bifidobacterium bifidum EPS DA-LAIM increased nitric oxide production in RAW 264.7 macrophage cells, indicating its immunostimulatory activity. Bifidobacterium bifidum EPS DA-LAIM also exhibited high gastrointestinal tract tolerance, gut adhesion ability, and antioxidant activity. These results suggest that EPS from B. bifidum EPS DA-LAIM is a potentially useful prebiotic material, and B. bifidum EPS DA-LAIM could be applied as a probiotic candidate.
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