Honeyberry-derived carbon quantum dots ameliorate LPS-induced neuroinflammation and oxidative stress through Nrf2/HO-1 signalling in HMC3 cellsopen access
- Authors
- Sanjay, Sanjay; Sharma, Anshul; Lee, Hae-Jeung
- Issue Date
- Dec-2023
- Publisher
- TAYLOR & FRANCIS LTD
- Keywords
- Carbon quantum dots; Lonicera caerulea; lipopolysaccharide; antioxidant; anti-inflammation
- Citation
- ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY, v.51, no.1, pp.95 - 107
- Journal Title
- ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
- Volume
- 51
- Number
- 1
- Start Page
- 95
- End Page
- 107
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/87852
- DOI
- 10.1080/21691401.2023.2179062
- ISSN
- 2169-1401
- Abstract
- Carbon quantum dots (CQDs) were synthesized from blue honeysuckle (Lonicera caerulea) berry fruit extracts using a well-known, cost-effective, and environmental friendly hydrothermal process. The material was characterized using UV-vis spectroscopy, photoluminescence (PL), XPS, and TEM studies. The as -synthesized carbon dots exhibit excellent PL properties, with a quantum yield of -35.92%. CQDs vary in size from -2 nm to 9 nm. This study established the neuroprotective effects of CQDs against lipopolysaccharide (LPS)-induced human microglial cell model. LPS was found to induce cytotoxicity, reactive oxygen species, and pro-inflammatory cytokines interleukin (IL)-113, IL-6, and tumour necrosis factor -a) and downregulated enzymatic antioxidants such as nuclear factor-erythroid factor 2-related factor 2 (Nrf2), superoxide dismutase, catalase, haem oxygenase (HO)-1, HO-2, and glutathione peroxidase, while CQDs treatment reversed LPS induced cytotoxicity, induced anti-inflammatory cytokines (IL-4, IL-10, and transforming growth factor 13) and induce enzymatic antioxidants both at transcriptional and translational levels. The study suggested the potential role of CQDs prepared from Lonicera caerulea, as anti-inflammatory and antioxidative agents in neuroinflammatory and neurodegenerative diseases. In addition, CQDs could be exploited in various biomedical applications such as biosensing, drug delivery and tissue engineering. <br />[GRAPHICAL ABSTRACT]
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