Enzymatic synthesis of 2-deoxyglucose-containing maltooligosaccharides for tracing the location of glucose absorption from starch digestion
- Authors
- Lee, Byung-Hoo; Koh, Dong-Wan; Territo, Paul R.; Park, Cheon-Seok; Hamaker, Bruce R.; Yoo, Sang-Ho
- Issue Date
- 5-Nov-2015
- Publisher
- ELSEVIER SCI LTD
- Keywords
- 2-Deoxyglucose (2-DG); Amylosucrase; Glucose absorption; Maltooligosaccharides; Mucosal alpha-glucosidases
- Citation
- CARBOHYDRATE POLYMERS, v.132, pp.41 - 49
- Journal Title
- CARBOHYDRATE POLYMERS
- Volume
- 132
- Start Page
- 41
- End Page
- 49
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/9914
- DOI
- 10.1016/j.carbpol.2015.06.012
- ISSN
- 0144-8617
- Abstract
- The ileal brake mechanism which induces a potentially beneficial slower gastric emptying rate and increased satiety is triggered by macronutrients including glucose from glycemic carbohydrates. For optimization of this diet-induced health benefit, there is the need for a way to determine the location of glucose deposition in the small intestine. Labeled 2-deoxyglucose (2-DG) can be used to trace the location of glucose absorption due to its accumulative property in the small intestine enterocytes. However, because pure glucose, or 2-DG, is directly absorbed in the proximal small intestine, we designed 2-DG containing maltooligosaccharides (2-DG-MOs) that can be used with a mild alpha-glucosidase inhibitor to attain an analytical method for determining location-specific delivery of glucose and its physiological effect. (C) 2015 Elsevier Ltd. All rights reserved.
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Collections - 바이오나노대학 > 식품생물공학과 > 1. Journal Articles
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