고지방식이유도 비만(High-fat diet-induced) 마우스를 이용한 혼합유산균(Bifidobacterium animalis ssp. Lactis, Lactobacillus rhamnosus)의 항비만 효과 검증

Abstract

The prevalence of obesity is steadily growing worldwide, causing several severe complications, including type 2 diabetes and cardiovascular diseases. With the importance of preventive approaches to obesity, related nutraceuticals and compounds are developing. Probiotics are attracting attention as a substance that is effective against obesity. Among the probiotics, Lactobacillus rhamnosus Lb102 and Bifidobacterium animalis ssp. Bf141 individually has the effect of preventing metabolic syndrome, including anti-obesity. Therefore, we examined the effect of a mixture of Lactobacillus rhamnosus Lb102 and Bifidobacterium animalis ssp. Bf141. The mixture of Lactobacillus rhamnosus Lb102 (Lb102) and Bifidobacterium animalis ssp. Bf141 (Bf141) was administered to a high-fat diet (HFD, 60% kcal from fat)-induced obese mice for eight weeks. The probiotics mixture did not alter body weight, feed intake, and body adiposity, meaning the rescue of obesity was ineffective. Furthermore, there was no difference in the liver weight, which is the center of lipid synthesis. In addition, the probiotics mixture did not modify fecal lipid content, an indicator of lipid digestion and absorption. Serum triglycerides and total cholesterol levels also remained unchanged. In conclusion, these results imply that the probiotics mixture of Lb102 and Bf141 had no anti-obesity outcome in HFD-induced obese mice.