Omega-3 fatty acid decreases oleic acid by decreasing SCD-1 expression in the liver and kidney of a cyclosporine-induced nephropathy rat modelopen access
- Authors
- Lee, Su Mi; Lee, Mi Hwa; Son, Young Ki; Kim, Seong Eun; Park, Yongsoon; Rha, Seo Hee; An, Won Suk
- Issue Date
- Jan-2019
- Publisher
- TAYLOR & FRANCIS LTD
- Keywords
- Cyclosporine; fatty acid; kidney; liver; omega-3; oleic acid
- Citation
- RENAL FAILURE, v.41, no.1, pp.211 - 219
- Indexed
- SCIE
SCOPUS
- Journal Title
- RENAL FAILURE
- Volume
- 41
- Number
- 1
- Start Page
- 211
- End Page
- 219
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/148517
- DOI
- 10.1080/0886022X.2019.1591996
- ISSN
- 0886-022X
- Abstract
- Aim: Stearoyl-CoA desaturase (SCD)-1 and elongase-6 (Elovl-6) are associated with fatty acid (FA) synthesis. We evaluated the effect of omega-3 FA on erythrocyte membrane FA contents through SCD-1 and Elovl-6 expression in the liver and kidney of a cyclosporine (CsA)-induced rat model. Methods: Male Sprague Dawley rats were divided into control, CsA, and CsA treated with omega-3 FA groups. We measured SCD-1 and Elovl-6 expression levels via western blot and immunohistochemistry analysis. Results: Erythrocyte membrane oleic acid content was lower in the CsA with omega-3 FA group compared to the CsA group. Compared to the control group, CsA-induced rats showed elevated SCD-1 expression in the kidney and liver, which omega-3 FA treatment reversed. Elovl-6 expression was increased in the liver, but decreased in the kidney in CsA group compared to control, which omega-3 FA treatment also reversed. Conclusions: Omega-3 FA supplementation decreased erythrocyte membrane oleic acid content by modulating SCD-1 and Elovl-6 expression in the kidney and liver of CsA-induced rats.
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Collections - 서울 생활과학대학 > 서울 식품영양학과 > 1. Journal Articles
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