Hovenia dulcis Extract Attenuates High-Fat Diet-Induced Hepatic Lipid Accumulation and Hypertriglyceridemia in C57BL/6 Mice
- Authors
- Park, Kibeum; Yoon, Hyo-Jung; Imm, Jee-Young; Go, Gwang-woong
- Issue Date
- Jan-2019
- Publisher
- MARY ANN LIEBERT, INC
- Keywords
- antioxidant enzymes; hepatic lipid accumulation; Hovenia dulcis Thunb. extract; hyperlipidemia
- Citation
- JOURNAL OF MEDICINAL FOOD, v.22, no.1, pp.74 - 80
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- JOURNAL OF MEDICINAL FOOD
- Volume
- 22
- Number
- 1
- Start Page
- 74
- End Page
- 80
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/148564
- DOI
- 10.1089/jmf.2018.4224
- ISSN
- 1096-620X
- Abstract
- The effects of dietary supplementation with aqueous Hovenia dulcis Thunb. extract (HDE) (20 weeks) on high-fat diet (HFD)-induced nonalcoholic fatty liver disease and dyslipidemia were evaluated in mice. Supplementation with 200 and 800 mg/kg feed HDE (HDE200 and HDE800, respectively) resulted in no significant difference in growth in the HFD-fed groups. The triglyceride (TG) levels and free fatty acids were significantly decreased, whereas high-density lipoprotein cholesterol was increased in the HDE800 group (P < .05). The hepatic intracellular TGs were significantly decreased in the HDE-fed groups and lipogenic enzymes (acetyl CoA carboxylase, fatty acid synthase, stearoyl CoA desaturase, and diacylglycerol transferase) in the liver were significantly downregulated by HDE supplementation (P < .05). The diminished serum antioxidant enzyme activities in the HFD group were effectively restored by HDE supplementation, which also contributed to the attenuation of hyperlipidemia.
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