Preparation, characterization, and cellular uptake of resveratrol-loaded trimethyl chitosan nanoparticlesopen access
- Authors
- Min, Jeong Bin; Kim, Eun Suh; Lee, Ji-Soo; Lee, Hyeon Gyu
- Issue Date
- Apr-2018
- Publisher
- KOREAN SOCIETY FOOD SCIENCE & TECHNOLOGY-KOSFOST
- Keywords
- Trimethyl chitosan; Nanoencapsulation; Controlled release; Cellular uptake; Cytotoxicity
- Citation
- FOOD SCIENCE AND BIOTECHNOLOGY, v.27, no.2, pp.441 - 450
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- FOOD SCIENCE AND BIOTECHNOLOGY
- Volume
- 27
- Number
- 2
- Start Page
- 441
- End Page
- 450
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/150257
- DOI
- 10.1007/s10068-017-0272-2
- ISSN
- 1226-7708
- Abstract
- The aim of the study was to encapsulate resveratrol (RV) in trimethyl chitosan (TMC) nanoparticles cross-linked with tripolyphosphate (TPP) and/or alginate to achieve controlled release and improved cellular uptake. TMC (degree of quaternization of 78%) was prepared by reacting purified chitosan with iodomethane. Three types of RV-loaded TMC nanoparticles were prepared: TMC–TPP (TP-NPs), TMC–alginate (TA-NPs), and TMC–alginate–TPP (TAP-NPs). TA-NPs and TAP-NPs showed lower particle size and encapsulation efficiency (EE), better distribution, and more sustained release than TP-NPs due to the high molecular weight and viscous property of alginate. Caco-2 cellular uptake of RV was improved by TMC nanoencapsulation, and TP-NPs showed the highest uptake due to its significantly higher EE. Compared with TAP-NPs, TA-NPs with higher positive surface charge showed higher cellular uptake. Moreover, Caco-2 cell growth-inhibiting activity of RV was significantly increased by TMC nanoencapsulation and TP-NPs showed the significantly highest activity with a good agreement with the permeability results.
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