Tricin, a methylated cereal flavone, suppresses fat accumulation by downregulating AKT and mTOR in 3T3-L1 preadipocytes
- Authors
- Lee, Dabeen; Go, Gwang-Woong; Imm, Jee-Young
- Issue Date
- Oct-2016
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- Tricin; Adipogenesis; Molecular mechanism; 3T3-L1 adipocytes
- Citation
- JOURNAL OF FUNCTIONAL FOODS, v.26, pp.548 - 556
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF FUNCTIONAL FOODS
- Volume
- 26
- Start Page
- 548
- End Page
- 556
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/153726
- DOI
- 10.1016/j.jff.2016.08.023
- ISSN
- 1756-4646
- Abstract
- The anti-adipogenic effect of tricin (5, 7, 4'-trihydroxy-3',5'-dimethoxyflavone), a flavone frequently found in cereal crops, and its underlying molecular mechanism were evaluated in 3T3-L1 preadipocytes. Tricin treatment (5–20 µM) significantly inhibited triacylglycerol (TG) accumulation without showing cytotoxicity. The expression of protein kinase B (AKT) was decreased by 80% using 20 µM tricin. The inhibition of mammalian target of rapamycin (mTOR) by tricin led to a significant suppression of the protein levels of CCAAT/enhancer-binding protein alpha (C/EBP-α), peroxisome proliferator-activated receptor gamma (PPAR-γ) and nuclear sterol regulatory element-binding protein 1 (SREBP-1). These results suggest that tricin regulates adipogenesis by targeting the AKT/mTORC1/SREBP-1 pathway in the adipose tissue and it could be used as an anti-obesity agent.
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