Sorghum extract exerts cholesterol-lowering effects through the regulation of hepatic cholesterol metabolism in hypercholesterolemic mice
- Authors
- Kim, Eunyoung; Kim, Sehee; Park, Yongsoon
- Issue Date
- May-2015
- Publisher
- TAYLOR & FRANCIS LTD
- Keywords
- Hepatic protein expression; high cholesterol; mice; sorghum
- Citation
- INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION, v.66, no.3, pp.308 - 313
- Indexed
- SCIE
SCOPUS
- Journal Title
- INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
- Volume
- 66
- Number
- 3
- Start Page
- 308
- End Page
- 313
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/157319
- DOI
- 10.3109/09637486.2014.1000839
- ISSN
- 0963-7486
- Abstract
- The purpose of this study is to investigate that sorghum extract (SE) exerts cholesterol-lowering effects through the regulation of hepatic cholesterol metabolism-related protein expression. C57BL/6 mice were fed a modified AIN-93G diet (NC) with saline, or a modified AIN-93G diet with 2% cholesterol and 0.25% cholic acid with either saline (HC) or 600 mg SE/kg body weight (HC-SE). Levels of total cholesterol and triglycerides in serum and liver were significantly lower in HC-SE than in HC. The expression of 3-hydroxy-3-methylglutaryl coenzyme A reductase, sterol regulatory elementary binding protein2 and fatty acid synthase were significantly lower, whereas phosphorylated AMP-activated protein kinase expression was significantly higher in HC-SE than in HC. Cholesterol 7-alpha hydroxylase expression was also significantly higher in mice given SE than in those given HC. These results suggest that the cholesterol-lowering effect of SE may be related to the regulation of hepatic cholesterol metabolism in this mouse model.
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