Anti-inflammation effect of Exercise and Korean red ginseng in aging model rats with diet-induced atherosclerosisopen access
- Authors
- Lee, Jin; Cho, Joon-Yong; Kim, Won-Kyu
- Issue Date
- Jun-2014
- Publisher
- KOREAN NUTRITION SOC
- Keywords
- Korea red ginseng; exercise; lipid profiles; inflammation; atherosclerosis
- Citation
- NUTRITION RESEARCH AND PRACTICE, v.8, no.3, pp.284 - 291
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- NUTRITION RESEARCH AND PRACTICE
- Volume
- 8
- Number
- 3
- Start Page
- 284
- End Page
- 291
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/159842
- DOI
- 10.4162/nrp.2014.8.3.284
- ISSN
- 1976-1457
- Abstract
- BACKGROUND/OBJECTIVES: The aim of this study was to investigate the effects of exercise (EX) and Korean red ginseng (KRG) on inflammation mechanism in aging model rats with diet-induced atherosclerosis.
MATERIALS/METHODS: Forty-eight male Sprague-Dawley rats were divided into 6 groups: Young control (Y-C), Aging control (A-C), A-C with HFD (AHF), AHF with EX (AHF-EX), AHF-EX with KRG (AHF-EX+RG), and AHF with KRG (AHF-RG). Aging was induced by D-gal (100mg/kg) and atherosclerosis was induced by HFD (60% fat) for 9 weeks. The experimental rats were performed swimming (60 min/day, 5 days/week) and supplied KRG orally (dose of 200 mg/kg) for 8 weeks. All rat aorta samples were harvested for biochemical and immunohistochemical analyses.
REULTS: The EX and KRG supplementation significantly inhibited body weight and levels of TC, TG, LDL-C, and enhance of HDL-C compared with untreated AHF groups. AHF-EX, AHF-EX+RG, and AHF-RG group showed a decreased plasma CRP and increase plasma NO activities compared to AHF group. In addition, these groups revealed reduced 4-HNE, NF-kB, TNF-a, IL-6, COX-2, ICAM-1, VCAM-1 and enhanced eNOS expression in the aorta.
CONCLUSION: These results suggest that EX alone, KRG alone, and combined treatment of EX and KRG may be an effective anti-inflammatory therapeutic for the atherosclerosis, possibly acting via the decreased of CRP and pro-inflammation proteins and the increased NO and eNOS.
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