N-3 polyunsaturated fatty acid consumption produces neurobiological effects associated with prevention of depression in rats after the forced swimming test
- Authors
- Park, Yongsoon; Moon, Hyoun-Jung; Kim, Seok-Hyeon
- Issue Date
- Aug-2012
- Publisher
- ELSEVIER SCIENCE INC
- Keywords
- BDNF; CREB; Cytokines; Depression; Forced swimming test; n-3 polyunsaturated fatty acids
- Citation
- JOURNAL OF NUTRITIONAL BIOCHEMISTRY, v.23, no.8, pp.924 - 928
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF NUTRITIONAL BIOCHEMISTRY
- Volume
- 23
- Number
- 8
- Start Page
- 924
- End Page
- 928
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/164986
- DOI
- 10.1016/j.jnutbio.2011.04.018
- ISSN
- 0955-2863
- Abstract
- Epidemiological data and clinical trials suggest that n-3 polyunsaturated fatty acids (PUFA) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have preventive and therapeutic effects on depression; however, the underlying mechanism remains elusive. The present study aimed to examine the behavioral effects and antidepressant mechanism of n-3 PUFA using a forced swimming test. Eleven-week-old male Sprague Dawley rats were fed an American Institute of Nutrition-93M diet containing 0%, 0.5% or 1% EPA and DHA relative to the total energy intake in their diet for 12 weeks (n=8 per group). Total dietary intake, body weight and hippocampus weights were not significantly different among groups. The groups administered 0.5% and 1% EPA+DHA diets had significantly higher levels of n-3 PUFA in their brain phospholipids compared to those in the control group. The immobility time was significantly decreased and the climbing time was significantly increased in the 0.5% and 1% EPA+DHA groups compared with those in the 0% EPA+DHA group. Plasma serotonin concentration and hippocampus c-AMP response element binding protein (CREB) expression were significantly increased in the 0.5% and 1% EPA+DHA groups compared with those in the 0% EPA+DHA group. Conversely, interleukin (IL)-6 expression was significantly reduced in the 0.5% and 1% EPA+DHA groups compared with that in the 0% EPA+DHA group. However, there were no dose-dependent effects of n-3 PUFA and no significant differences in expressions of IL-1 beta, tumor necrosis factor-alpha, brain-derived neurotrophic factor or phosphorylated CREB. In conclusion, long-term intake of EPA+DHA induced antidepressant-like effects in rats and overexpression of CREB via decreased IL-6 expression.
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