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Effect of Amination on the biological activity of beta-glucan from Sangwhang (Phellinus linteus)
- Authors
- Bae, In Young; Shin, Ji-Yoon; Lee, Hyeon Gyu
- Issue Date
- Jun-2008
- Publisher
- KOREAN SOCIETY FOOD SCIENCE & TECHNOLOGY-KOSFOST
- Keywords
- sangwhang; beta-glucan; amination; nitric oxide; cytotoxic activity
- Citation
- FOOD SCIENCE AND BIOTECHNOLOGY, v.17, no.3, pp.683 - 686
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- FOOD SCIENCE AND BIOTECHNOLOGY
- Volume
- 17
- Number
- 3
- Start Page
- 683
- End Page
- 686
- ISSN
- 1226-7708
- Abstract
- beta-Glucans, which were isolated from sangwhang (Phellinus linteus), were subjected to reductive amination and the biological properties of the derivative were investigated. The degree of substitution of the aminated sangwhang beta-glucan was calculated by elemental analysis to be 1.13. Bronchoalveolar lavage (BAL) experiments showed that the aminated derivative increased nitric oxide production. In addition, the amination enhanced in vitro cytotoxic activities against HT1080 and SNU-C2A cell lines. Thus, the aminated derivative is shown to enhance immune systems by the incorporation of amino groups into the polyrner structure.
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Collections - 서울 생활과학대학 > 서울 식품영양학과 > 1. Journal Articles
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Related Researcher
- Lee, Hyeon Gyu
- COLLEGE OF HUMAN ECOLOGY (DEPARTMENT OF FOOD & NUTRITION)