Association between Omega-3 Index and Hyperglycemia Depending on Body Mass Index among Adults in the United Statesopen access
- Authors
- Jo, Sunyoung; Harris, William S.; Tintle, Nathan L.; Park, Yongsoon
- Issue Date
- Oct-2022
- Publisher
- MDPI
- Keywords
- body mass index; Omega-3 Index; n-3 polyunsaturated fatty acids; hyperglycemia; type 2 diabetes
- Citation
- NUTRIENTS, v.14, no.20, pp.1 - 11
- Indexed
- SCIE
SCOPUS
- Journal Title
- NUTRIENTS
- Volume
- 14
- Number
- 20
- Start Page
- 1
- End Page
- 11
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/172938
- DOI
- 10.3390/nu14204407
- ISSN
- 2072-6643
- Abstract
- There is inconsistency regarding the association between long-chain n-3 polyunsaturated fatty acids such as eicosapentaenoic acid (EPA; 20:5n3) and docosahexaenoic acid (DHA; 22:6n3) and the risk of type 2 diabetes. The present study aimed to investigate the association between the Omega-3 Index (erythrocyte EPA + DHA) and glycemic status as a function of body mass index (BMI). Cross-sectional data from routine clinical laboratory testing with a total of 100,572 people aged over 18 years and BMI >= 18.5 kg/m(2) were included. Of the patients, 10% were hyperglycemic (fasting plasma glucose levels >= 126 mg/dL) and 24.7% were of normal weight, 35.0% were overweight, and 40.3% were obese. Odds ratios (ORs) of being hyperglycemic were inversely associated with the Omega-3 Index, but weakened as BMI increased. Thus, ORs (95% CI) comparing quintile 5 with quintile 1 were 0.54 (0.44-0.66) in the normal weight group, 0.70 (0.61-0.79) in the overweight group, and 0.74 (0.67-0.81) in the obese group. Similar patterns were seen for EPA and DHA separately. The present study suggested that a low Omega-3 Index is associated with a greater risk of disordered glucose metabolism and this is independent of BMI.
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