Erythrocyte alpha-linolenic acid is associated with the risk for mild dementia in Korean elderly
- Authors
- Kim, Malgeunsinae; Nam, Jung Hyun; Oh, Dong Hoon; Park, Yongsoon
- Issue Date
- Nov-2010
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- n-3 polyunsaturated fatty acids; alpha-Linolenic acid; Erythrocyte; Dementia; Elderly
- Citation
- NUTRITION RESEARCH, v.30, no.11, pp.756 - 761
- Indexed
- SCIE
SCOPUS
- Journal Title
- NUTRITION RESEARCH
- Volume
- 30
- Number
- 11
- Start Page
- 756
- End Page
- 761
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/173479
- DOI
- 10.1016/j.nutres.2010.10.005
- ISSN
- 0271-5317
- Abstract
- n-3 polyunsaturated fatty acids (PUFA) play an important role in brain development and function, but there is conflicting evidence between the relationship of n-3 PUFA and dementia in the elderly. The purpose of the present study was to test the hypothesis that n-3 PUFA content of erythrocytes is associated with mild dementia in elderly Koreans. Fifty-seven elderly (age 65 years) patients (19 male, 38 female) were recruited, and indicators of dementia (intake, erythrocyte fatty acid composition, and Mini-Mental Status Examination-Korean Version [MMSE-K]) were evaluated. Patients were divided into groups based on their MMSE-K score: normal control group (score >21 [n = 24]) and deficit group (score 21 [n = 33]). Multivariate-adjusted regression analysis showed that a higher level of alpha-linolenic acid (ALA; 18:3n-3) significantly decreased the risk of mild dementia after adjusting for age, sex, and height. MMSE-K score was also significantly and positively associated with erythrocyte ALA and total n-3 PUFA. However, erythrocyte levels of docosahexaenoic acid (22:6n-3) and eicosapentaenoic acid (20:5n-3) were not significantly related with the risk of mild dementia and MMSE-K score. Dietary intake was also not significantly associated with the risk of mild dementia and MMSE-K score after adjusting for age, sex, height, and energy intake. In conclusion, ALA derived from plant sources of n-3 PUFA, but not eicosapentaenoic acid and docosahexaenoic acid from fish, decreased the risk for mild dementia among the Korean elderly.
- Files in This Item
-
Go to Link
- Appears in
Collections - 서울 생활과학대학 > 서울 식품영양학과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/173479)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.