Tackling range uncertainty in proton therapy: Development and evaluation of a new multi-slit prompt-gamma camera (MSPGC) systemopen access
- Authors
- Ku, Youngmo; Choi, Sehoon; Cho, Jaeho; Jang, Sehyun; Jeong, Jong Hwi; Kim, Sung Hun; Cho, Sungkoo; Kim, Chan Hyeong
- Issue Date
- Sep-2023
- Publisher
- Korean Nuclear Society
- Keywords
- Multi-slit prompt-gamma camera; Proton therapy; Range measurement; Range uncertainty; Range verification
- Citation
- Nuclear Engineering and Technology, v.55, no.9, pp.3140 - 3149
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- Nuclear Engineering and Technology
- Volume
- 55
- Number
- 9
- Start Page
- 3140
- End Page
- 3149
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/192983
- DOI
- 10.1016/j.net.2023.05.028
- ISSN
- 1738-5733
- Abstract
- In theory, the sharp dose falloff at the distal end of a proton beam allows for high conformal dose to the target. However, conformity has not been fully achieved in practice, primarily due to beam range uncertainty, which is approximately 4% and varies slightly across institutions. To address this issue, we developed a new range verification system prototype: a multi-slit prompt-gamma camera (MSPGC). This system features high prompt-gamma detection sensitivity, an advanced range estimation algorithm, and a precise camera positioning system. We evaluated the range measurement precision of the prototype for single spot beams with varying energies, proton quantities, and positions, as well as for spot-scanning proton beams in a simulated SSPT treatment using a phantom. Our results demonstrated high accuracy (<0.4 mm) in range measurement for the tested beam energies and positions. Measurement precision increased significantly with the number of protons, achieving 1% precision with 5 × 108 protons. For spot-scanning proton beams, the prototype ensured more than 5 × 108 protons per spot with a 7 mm or larger spot aggregation, achieving 1% range measurement precision. Based on these findings, we anticipate that the clinical application of the new prototype will reduce range uncertainty (currently approximately 4%) to 1% or less.
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