Applicability of X-ray microscopy to non-contact tablet mass estimation
- Authors
- Kim, Jiseok; Yim, Chewook; Kim, Yongkyun
- Issue Date
- Jun-2018
- Publisher
- SPRINGER
- Keywords
- Mass measurement; Tablet manufacturing; X-ray transmittance; Imaging plate detector; Volume measurement
- Citation
- JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, v.316, no.3, pp.1033 - 1038
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
- Volume
- 316
- Number
- 3
- Start Page
- 1033
- End Page
- 1038
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/2359
- DOI
- 10.1007/s10967-018-5867-4
- ISSN
- 0236-5731
- Abstract
- The pharmaceutical tablet manufacturing process requires a tablet mass measuring step to ensure that all tablets have the prescribed dosage. The digital scales commonly used for that purpose require tens of seconds to stabilize, resulting in a substantial slow-down of the manufacturing process. The alternative visual approaches are fallible because of the potential existence of voids and cracks in the tablets. This paper uses an X-ray microscopy for mass measurement. Albeit with some constraints concerning tablet size and constituents, the approach can measure a tablet's mass in under one second, and may constitute, in the future, a viable and practical approach.
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