하수오와 백하수오의 에탄올 추출물에 의한 B16/F10 Melanoma 세포주의 멜라닌 생성 억제효과Inhibitory Effects of Ethanol Extracts from Polygoni multiflori radix and Cynanchi wilfordii radix on Melanogenesis in Melanoma Cells
- Other Titles
- Inhibitory Effects of Ethanol Extracts from Polygoni multiflori radix and Cynanchi wilfordii radix on Melanogenesis in Melanoma Cells
- Authors
- 서희; 서근영; 고수지; 박영현
- Issue Date
- 2011
- Publisher
- 한국식품영양과학회
- Keywords
- Polygoni multiflori radix; Cynanchi wilfordii radix; melanin; tyrosinase; antioxidant
- Citation
- 한국식품영양과학회지, v.40, no.8, pp.1086 - 1091
- Journal Title
- 한국식품영양과학회지
- Volume
- 40
- Number
- 8
- Start Page
- 1086
- End Page
- 1091
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/17115
- ISSN
- 1226-3311
- Abstract
- Anti-oxidative activity and tyrosinase inhibitory activity of various ethanol extracts of Polygoni multiflori radix (PMR) and Cynanchi wilfordii radix (CWR) were compared to identify an anti-oxidant and whitening agent source from nature. We conducted an investigation into the anti-oxidant activities of PMR and CWR ethanol extracts by measuring total polyphenol content, total flavonoid content, and ABTS radical capacity. The total polyphenol contents of PMR and CWR were 17.31±0.54 mg GA/eq g, and 2.75±0.22 mg GA/eq g, respectively. The total flavonoid contents of PMR and CWR were 6.38±0.39 mg naringine/eq g, and 1.34±0.09 mg naringine/eq g, respectively. The 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) radical decolorization of PMR and CWR were 96.89±0.21% at 1 mg/mL and 93.49±0.76% at 50 mg/mL. Melanoma cells were cultured with the PMR and CWR ethanol extracts for 48 hr, and total melanin content as a final product and the activity of tyrosinase, a key enzyme, in melanogenesis, were estimated. The PMR and CWR ethanol extracts increased melanin content and tyrosinase activity in a dose-dependent manner. These results suggest that PMR and CWR ethanol extracts could be useful as a skin whitening agent.
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