Relationship between vitamin K status, bone mineral density, and hs-CRP in young Korean women
- Authors
- Kim, Misung; Kim, Heeseon; Sohn, Cheongmin
- Issue Date
- Dec-2010
- Publisher
- 한국영양학회
- Keywords
- Vitamin K; osteocalcin; undercarboxylated osteocalcin; bone mineral density; hs-CRP
- Citation
- Nutrition Research and Practice, v.4, no.6, pp 507 - 514
- Pages
- 8
- Journal Title
- Nutrition Research and Practice
- Volume
- 4
- Number
- 6
- Start Page
- 507
- End Page
- 514
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/17478
- DOI
- 10.4162/nrp.2010.4.6.507
- ISSN
- 1976-1457
2005-6168
- Abstract
- Vitamin K intake has been reported as an essential factor for bone formation. The current study was conducted under the hypothesis that insufficient vitamin K intake would affect inflammatory markers and bone mineral density in young adult women. The study was a cross-sectional design that included 75 women in their 20s. Physical assessments, bone mineral density measurements, 24-hr dietary recalls, and biochemical assessments for high sensitivity C-reactive protein (hs-CRP) and percentages of undercarboxylated osteocalcin (%ucOC) were performed. An analysis of vitamin K nutritional status was performed comparing first, second, and third tertiles of intake based on %ucOC in plasma. Vitamin K intake levels in the first, second, and third tertiles were 94.88 +/- 51.48 mu g, 73.85 +/- 45.15 mu g, and 62.58 +/- 39.92 mu g, respectively (P < 0.05). The T-scores of the first and third tertiles were 1.06 and -0.03, respectively, indicating that bone mineral density was significantly lower in the group with lower vitamin K intake (P < 0.05). There was a tendency for different serum hs-CRP concentrations between the first (0.04 +/- 0.02) and third tertiles (0.11 +/- 0.18), however this was not statistically significant. Regression analysis was performed to identify the correlations between vitamin K nutritional status, inflammatory markers, and bone mineral density after adjusting for age and BMI. Serum hs-CRP concentrations were positively correlated with vitamin K deficiency status (P < 0.05). And bone mineral density, which was represented by speed, was negatively correlated with vitamin K deficiency status (P < 0.05). In conclusion, status of vitamin K affects inflammatory status and bone formation. Therefore, sufficient intake of vitamin K is required to secure peak bone mass in young adult women.
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Collections - College of Natural Sciences > Department of Food Science and Nutrition > 1. Journal Articles
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