Type 2 diabetes and its genetic susceptibility are associated with increased severity and mortality of COVID-19 in UK Biobankopen access
- Authors
- Lee, Aeyeon; Seo, Jieun; Park, Seunghwan; Cho, Youngkwang; Kim, Gaeun; Li, Jun; Liang, Liming; Park, Taesung; Chung, Wonil
- Issue Date
- Jan-2024
- Publisher
- NATURE PORTFOLIO
- Citation
- COMMUNICATIONS BIOLOGY, v.7, no.1
- Journal Title
- COMMUNICATIONS BIOLOGY
- Volume
- 7
- Number
- 1
- URI
- https://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/49171
- DOI
- 10.1038/s42003-024-05799-1
- ISSN
- 2399-3642
2399-3642
- Abstract
- Type 2 diabetes (T2D) is known as one of the important risk factors for the severity and mortality of COVID-19. Here, we evaluate the impact of T2D and its genetic susceptibility on the severity and mortality of COVID-19, using 459,119 individuals in UK Biobank. Utilizing the polygenic risk scores (PRS) for T2D, we identified a significant association between T2D or T2D PRS, and COVID-19 severity. We further discovered the efficacy of vaccination and the pivotal role of T2D-related genetics in the pathogenesis of severe COVID-19. Moreover, we found that individuals with T2D or those in the high T2D PRS group had a significantly increased mortality rate. We also observed that the mortality rate for SARS-CoV-2-infected patients was approximately 2 to 7 times higher than for those not infected, depending on the time of infection. These findings emphasize the potential of T2D PRS in estimating the severity and mortality of COVID-19. Study of 459,119 UK Biobank participants reveals that type 2 diabetes (T2D) and a high genetic susceptibility to T2D significantly increase the severity and mortality rate in COVID-19 cases.
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